SBML Level 3 Package Proposal: Flux

This document describes an easy to implement package for storing information related 
to flux balance analysis of SBML Level 3 models (the FBA package). In addition, 
we provide an example of how this package may be implemented and used as a SBML
Level 2 annotation

ESTIMATION OF INCOME DISTRIBUTION AND DETECTION OF SUBPOPULATIONS: AN EXPLANATORY MODEL

Inequality and polarization analyses are complementary but conceptually different. They are usually implemented independently in practic e, with different a priori assumptions and different tools. In this paper, we develop a unique method to study simultaneously these different and complementary concerns. Based on mixture models, the method we develop includes at the same time : an estimation of income distribution with no a priori assumptions - a decomposition in several homogeneous subpopulations - an explanatory model to study the structure of the income distribution.

The mean, variance and limiting distribution of two statistics sensitive to phylogenetic tree balance

For two decades, the Colless index has been the most frequently used statistic for assessing the balance of phylogenetic trees. In this article, this statistic is studied under the Yule and uniform model of phylogenetic trees. The main tool of analysis is a coupling argument with another well-known index called the Sackin statistic. Asymptotics for the mean, variance and covariance of these two statistics are obtained, as well as their limiting joint distribution for large phylogenies. Under the Yule model, the limiting distribution arises as a solution of a functional fixed point equation. Under the uniform model, the limiting distribution is the Airy distribution. The cornerstone of this study is the fact that the probabilistic models for phylogenetic trees are strongly related to the random permutation and the Catalan models for binary search trees.Comment: Published at http://dx.doi.org/10.1214/105051606000000547 in the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org

Uniqueness Results for Second Order Bellman-Isaacs Equations under Quadratic Growth Assumptions and Applications

In this paper, we prove a comparison result between semicontinuous viscosity sub and supersolutions growing at most quadratically of second-order degenerate parabolic Hamilton-Jacobi-Bellman and Isaacs equations. As an application, we characterize the value function of a finite horizon stochastic control problem with unbounded controls as the unique viscosity solution of the corresponding dynamic programming equation

Targeting the tumor microenvironment in colorectal peritoneal metastases

Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (IP) delivery of chemotherapy, is limited. Increasingly, therefore, efforts are being developed to unravel the PM cascade and at understanding the PM-associated tumor microenvironment (TME) and peritoneal ecosystem as potential therapeutic targets. Here, we review recent insights in the structure and components of the TME in colorectal PM, and discuss how these may translate into novel therapeutic approaches aimed at re-engineering the metastasis-promoting activity of the stroma

Measurement of thermal conductance of silicon nanowires at low temperature

We have performed thermal conductance measurements on individual single crystalline silicon suspended nanowires. The nanowires (130 nm thick and 200 nm wide) are fabricated by e-beam lithography and suspended between two separated pads on Silicon On Insulator (SOI) substrate. We measure the thermal conductance of the phonon wave guide by the 3 method. The cross-section of the nanowire approaches the dominant phonon wavelength in silicon which is of the order of 100 nm at 1K. Above 1.3K the conductance behaves as T3, but a deviation is measured at the lowest temperature which can be attributed to the reduced geometry

"Barber pole turbulence" in large aspect ratio Taylor-Couette flow

Investigations of counter-rotating Taylor-Couette flow (TCF) in the narrow gap limit are conducted in a very large aspect ratio apparatus. The phase diagram is presented and compared to that obtained by Andereck et al. The spiral turbulence regime is studied by varying both internal and external Reynolds numbers. Spiral turbulence is shown to emerge from the fully turbulent regime via a continuous transition appearing first as a modulated turbulent state, which eventually relaxes locally to the laminar flow. The connection with the intermittent regimes of the plane Couette flow (pCf) is discussed

The relationships between organic farming and agroecology.

While acknowledging an extension of agroecology in the organic sector and a growing influence of agroecology in the academic world, we explore their relationships. These relationships cannot be reduced to an opposition between a scientific field and a practical domain. A Brazilian case study based on the analysis of researchers and social actors trajectories exemplifies the diversity of existing relations, whether inclusive or exclusive. With a literature review, this allows characterising the specific attributes of both organic agriculture and agroecology. We discuss them in the light of current challenges for organic farming research and development

Primordial Non-Gaussianity from the 21 cm Power Spectrum during the Epoch of Reionization

Primordial non-Gaussianity is a crucial test of inflationary cosmology. We consider the impact of non-Gaussianity on the ionization power spectrum from 21 cm emission at the epoch of reionization. We focus on the power spectrum on large scales at redshifts of 7 to 8 and explore the expected constraint on the local non-Gaussianity parameter f_(NL) for current and next-generation 21 cm experiments. We show that experiments such as SKA and MWA could measure f_(NL) values of order 10. This can be improved by an order of magnitude with a fast-Fourier transform telescope like Omniscope